Chelsea captain Cesar Azpilicueta was not in the matchday squad for the 5-1 win over Chesterfield in the FA Cup on Saturday.
The Spaniard picked up cramp in the first leg of the Carabao Cup semi-final against Tottenham last week and the decision was made to rest him for the game at the weekend. He should be available to face Spurs on Wednesday.
There is less certainty over the participation of Thiago Silva and N’Golo Kante. Both have contracted the virus and they will need to pass a test before being allowed to play in the second leg.
Trevoh Chalobah aggravated a hamstring injury in the 2-2 draw versus Liverpool earlier this month, and he is not expected to be back in action any time soon.
Reece James has not played since sustaining his own hamstring problem in the 1-1 draw against Brighton and he may only return to full fitness in mid-February. Ben Chilwell is out for the rest of the season with an ACL injury.